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Method: In the present study, wistar albino rats of either sex weighing 150-250 g were anesthetized by giving thiopentone sodium 45 mg/kg by i.p.

surgical technique for the induction of retinal ischemia was adopted from the earlier published method. Common carotid arteries were identified and separated carefully from vago-sympathetic nerve. Rats were made ischemic by occluding bi-common carotid arteries BCCAO with thread for 30 min, followed by reperfusion for 4 h by removing the occlusion. The drugs Hesperetin 20, 40 mg/kg and Naringenin 20, 40 mg/kg were administered 10 min before reperfusion.