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On the basis of evidence reviewed in this paper, we propose that altered expression or activity of the sodium-potassium-chloride transporter in the loop of Henle, in conjunction with events occurring in other segments of the nephron, possibly accounts for the altered diuretic response to these agents.

Thus the modulators of this altered expression/activity could penegra express dosage serve as important therapeutic targets for alternative diuretic regimens in these conditions.

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